2. Signaling Pathways
  3. Epigenetics
  4. Histone Acetyltransferase
  5. CBP/p300 Isoform
  6. CBP/p300 Degrader

CBP/p300 Degrader

CBP/p300 Degrader (1):

Cat. No. Product Name Effect Purity
  • HY-154984
    JET-209
    		Degrader 98.07%
    JET-209 is a potent CBP/p300 PROTAC degrader, with DC50 values of 0.05 nM and 0.2 nM for CBP and p300. JET-209 demonstrates remarkable anti-tumor activity against various acute leukemia cell lines and effectively inhibits tumor growth in xenograft tumor models. JET-209 can be used for the study of acute leukemia (Pink: CBP/p300 ligand (HY-175620); Blue: CRBN ligand (HY-132248); Black: Linker; CBP/p300 ligand + Linker (HY-175621)).